From jasmine absolute to Hedione®: Fragrances and enantiomers

A food-grade, medicinal, and essential raw material for perfumery, jasmine—particularly Jasminum grandiflorum L. and J. sambac—is distinguished by its iconic fragrance and unique organoleptic properties. Its olfactory signature is rooted in the stereochemistry of its compounds, particularly the influence of the enantiomeric profiles of methyl jasmonate and linalool, which are key determinants of perception thresholds, sensory quality, and the geographical authentication of extracts.

The rise of enantioselective catalysis has led to the development of iconic molecules (e.g., methyl dihydrojasmonate, Hedione®, and its enantiomerically enriched form Paradisone®), expanding the olfactory palette while reducing pressure on plant resources. Molecular chirality strongly affects biological activity and olfactory properties, while also contributing to the authentication of natural products. A rigorous stereochemical characterization of extracts also sheds light on the therapeutic properties (spasmolytic, dermatological, antioxidant, neuropsychosensory, etc.) of jasmine, supporting uses compatible with an integrative health approach. In this way, it becomes possible to connect traditional knowledge with a contemporary understanding of composition, properties, and mechanisms of action, thereby promoting therapeutic and clinical safety.